BONE MARROW (STERNUM)

Species: Rats and Mice
Organ: Bone marrow
Localization: Sternum
Number of sections: 1
Direction: Longitudinal horizontal
Sample size: 2 - 3 sternebrae
Remarks: Decalcified


Sternum with bone marrow.


Sternum with bone marrow.

The bone marrow is generally examined concurrently with the bone tissue. From this decalcified section it is possible to evaluate the cellularity, number of megakaryocytes and the stromal compartment. Examination of a bone marrow smear of a core sample from the femur may be useful for evaluation of iron content and more precise cytology.

See also:
      Bone
      Bone marrow smear
      Introduction

References
Kuper CF, Harleman JH, Richter-Reichelm HB, Vos JG (2000) Histopathologic approaches to detect changes indicative of immunotoxicity. Toxicol Pathol 28: 454–466
MacKenzie WF, Eustis SL (1990) Bone marrow. In: Boorman GA, Eustis SL, Elwell MR, Montgomery CA, Jr, MacKenzie WF (eds) Pathology of the Fischer rat. Reference and atlas. Academic Press, San Diego New York London, pp 421–488
Valli VE, McGrath JP, Chu I (2002) Hematopoietic system. In: Haschek WM, Rousseaux CG, Wallig MA (eds) Handbook of toxicologic pathology, 2nd edition, Vol 2. Academic Press, San Diego New York Boston, pp 647–679
Valli VE, Vileneuve DC, Reed B, Barsoum N, Smith G (1990) Evaluation of blood and bone marrow, rat. In: Jones TC, Ward JM, Mohr U, Hunt RD (eds) Monographs on pathology of laboratory animals. Hemopoietic system. Springer, Berlin Heidelberg New York Tokyo, pp 9–26
Wickramasinghe SN (1992) Bone marrow. In: Sternberg SS (ed) Histology for pathologists. Raven Press, New York, pp 1–31

Guidelines overview
    
 EMEAFDAMHWEPANTPOECDSTP
Bone marrow +1)++++++
Sternum  +     
1) "if needed"
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